What are 'active ingredients' anyway?

What are 'active ingredients' anyway? We see and hear it in commercials everywhere, and it seems that the marketers are trying to lead us into thinking that active ingredients are effective. Is it true? 

Maybe. MAYBE NOT.

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What is it then?

The FDA in US distinguishes between active and non-active ingredients in the labelling. It is

  • โ€œany component of a drug product intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease, or to affect the structure or any function of the body of humans or other animalsโ€™,
  • and includes โ€œthose components of the product that may undergo chemical change during the manufacture of the drug product and be present in the drug product in a modified form intended to furnish the specified activity or effectโ€[1].

The above definitions sounds โ€˜drugโ€™-related, and you might question, โ€˜does this apply to cosmetics?โ€™ Good question! The answer is: depends on what you define as โ€˜cosmeticsโ€™.

It does not apply to every cosmetic products

Active ingredients in โ€œOver-the-counterโ€ drugs refers to the ingredients that make the product โ€˜workโ€™. For example, Fluoride in toothpaste. The blurry parts comes in when actually the FDA looks at both OTC drugs, cosmetics, personal care products. And โ€˜active ingredientsโ€™ only apply to OTC drugs. This is because โ€˜if a cosmetic had an ingredient in it that changed the biochemistry of the skin or otherwise interfered with normal skin biology, then it would be an illegal drug. Cosmetics are not allowed to have drug effects.โ€™ [2]

If a cosmetic had an ingredient in it that changed the biochemistry of the skin or otherwise interfered with normal skin biology, then it would be an illegal drug. Cosmetics are not allowed to have drug effects.
— [2]

To make things even more confusing, there are some cosmetics / skincare products that are considered OTC drugs (*plus there isnโ€™t actually a clear definition of what cosmetics is versus skincare, so these are only names we createdโ€ฆ) For example,

  • Anti-acne products,
  • toothpaste & anti-cavity products,
  • topical anti-fungal like anti-rashes products,
  • hair growth / hair loss products,
  • sunscreen,
  • antiperspirant,
  • dandruff products, etc.
  • For more, see [3] & [4].

So.. What exactly are the active ingredients in my body lotion?

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Assuming the products in question don't have any special functions like reducing hair growth, skin whitening, etc., there is an opinion that โ€˜active ingredientsโ€™ in 'non-OTC drug' cosmetics is a marketing term to lead people into thinking that the ingredient works like active ingredients in in drug products. An example cited [2] explains that some products might claim Vitamin C is an active ingredient for skin lightening, but some lab studies might not support this, so technically it is not an โ€˜active ingredientโ€™ (in the OTC drug sense). But marketers like to use โ€˜active ingredientโ€™ in their labels to make you believe the product works.

This is not to say that your product doesn't work. What isn't an 'active ingredient' doesn't mean it is not effective. All I am trying to say is, do not fall into the trap that because a certain product contains 'active ingredient', that it is superior to its competitor products. 

The 'active ingredients' in your 'non-OTC drug' products probably refers to the ingredients that makes the product 'work' - but unlike the 'legit' active ingredients, these ingredients aren't listed in the FDA Monograph, where the amounts used and their effects are listed. For instance, the detergents in your face wash, the oil in your face cream, wax in your lip balm, etc.

What it means when we read ingredients list in Hong Kong

In Hong Kong, we do not have our own labelling requirements. Instead, we follow standards in Japan, the US, the EU and China. This means that if we want to decipher and make sense out of the ingredients list, we need to know whether the list follows the US or EU order.

So the next time you read an ingredient list, be clear of the purpose of the product and look for the ingredients that makes the product work.

  • Usually you will most likely see the 'base ingredient' on the ingredient list first, e.g. Aqua / water.
  • You might also see other 'control ingredients' or additives that are required to make sure the products are stable, i.e. preservatives, pH balancing, etc.
  • It's good to identify what are the 'aesthetic flourishes' that performs no functions but simply to make the product more attractive. These should be the least of your concern, as it is not related to whether the product works.
  • Some would consider aroma as part of the product offering, as there are indeed school of thought on aromatherapy that believes the right aroma can improve physiological and psychological wellbeing. 

Just another note on aroma

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Stay away from artificial fragrance or anything called 'parfum' or 'perfume' on the ingredient list.

  • Thanks to trade secret laws, manufacturers do not have to declare what chemicals (natural or synthetic) are used to create the scent. So there can be more than 100 ingredients in the perfume, but they never tell you! 
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  • Even products that claim to be 'unscented' can contain fragrance. This is because "the manufacturer may add just enough fragrance to mask the unpleasant smell of other ingredients, without giving the product a noticeable scent." [6]
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  • Essential oils are different from fragrance oils - essential oils are plant-derived, whereas fragrance oils are synthetic and man-made. You don't want fragrance oils - they are no different from 'perfume' or 'parfum' listed in point 1!
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  • Just because essential oils are natural doesn't mean they are good in quality. I can write another post soon on how natural & organic are different. Just an example - a natural product can contain pesticides!
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  • Essential oil doesn't necessarily smell good, just as plants can smell weird... 
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  • The dose of essential oils is important, as essential oils in its pure / 'neat' form should not be directly applied to the skin.  Some oils can be dermal irritants, dermal sensitizers, photosensitizers, mucous membrane irritants, etc. or to be avoided during pregnancy [I am no expert in this so I'm attempting to list what I find here, for more, see [7 & 8]. Too much can be lethal [8].
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  • So when it comes to using essential oils, you must consult or buy products from well-trained aromatherapists.

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Do NOT attempt to play around with it yourself.

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Hopefully this piece gives you more idea on how to read ingredient lists - on what to look for and what to avoid! Happy skincare-ing! xo